Contribution of Cardiorespiratory Coupling to the Irregular Dynamics of the Human Cardiovascular System

Irregularity is an important aspect of the cardiovascular system dynamics. Numerical indices irregularity, such as largest Lyapunov exponent and correlation dimension estimated from interbeat interval time series, are early markers diseases. However, there no consensus on origin irregularity in system. A common hypothesis suggests importance nonlinear bidirectional coupling between respiratory for irregularity. Experimental investigations this theory severely limited by capabilities modern medical equipment nonstationarity real biological systems. Therefore, we studied problem using a mathematical model coupled We compared numerical complexity simulating dynamics healthy subjects with blocked regulation frequency amplitude, which disturbs